Phosphodiesterase type 5 (PDE5) inhibitors are a class of drugs primarily utilized to treat erectile dysfunction (ED), which is the most prevalent form of male sexual dysfunction. These medications were fortuitously discovered to improve ED symptoms during research on their potential application for high blood pressure and angina.
ED is more common with advancing age, affecting an estimated 30 million to 50 million men in the United States. PDE5 inhibitors are often the initial therapy choice for individuals experiencing ED due to inadequate blood supply to the penis.
This article delves into the most frequently prescribed and the best medicine for erectile dysfunction available in the market, elucidating their mode of action, indications, and pricing.
ED can stem from psychological or physiological causes. While PDE5 inhibitors can effectively treat ED caused by physiological factors, they are not effective in treating ED caused by psychological factors such as stress or anxiety.
For psychological causes of ED, psychotherapy or counseling are viable treatment options.
Here is the list of PDE5 inhibitors that are available, namely
Let us examine each one of these PDE5 inhibitors in detail.
1. Sildenafil (Viagra)
Sildenafil, also known as Viagra, is the first extensively researched PDE5 inhibitor that was approved by the FDA in 1998 to treat ED in men. It works by increasing blood flow to the penis when sexually aroused, but only with sexual stimulation.
Duration of Effects and Dosage
PDE5 inhibitor Sildenafil or Viagra typically takes effect within an hour and lasts for about 4 hours, but the effects can last as long as 12 hours. The recommended dosage of sildenafil is between 25 to 100 milligrams per day.
Common Side Effects
Like other medications, sildenafil may cause side effects. Some of the most common ones include:
However, not everyone experiences side effects, and they are usually mild and short-lived.
The cost of sildenafil can vary depending on where it is purchased. Brand-name Viagra is often sold for a higher price. It is available as generic ED pills online under the brand-name of Kamajoy 100mg and Kamajoy 200mg.
2. Tadalafil (Cialis):
Tadalafil is a medication approved by the FDA in 2003 to treat erectile dysfunction (ED). It is also approved to treat benign prostate hyperplasia (BPH).
Dosage and Timing
Tadalafil should be taken at least half an hour before sexual activity, and it usually takes effect within 20 minutes. A typical daily dose ranges from 2.5 to 20 mg, with the effect lasting for 24 to 36 hours.
Longest Action PDE5 Inhibitor
Tadalafil has the longest action of any available PDE5 inhibitor, making it a popular choice among users.
Common Side Effects
As with any medication, there are potential side effects. Common side effects of tadalafil include:
The cost of Cialis varies and depends on the strength of the medication. Generic versions of tadalafil such as Tadanova 40mg, and Tadanova 80mg are also manufactured by several ED suppliers.
Vardenafil, sold under the brand names Levitra and Staxyn, is a type of medication known as a phosphodiesterase type 5 (PDE5) inhibitor. It is used to treat erectile dysfunction (ED) and works by increasing blood flow to the penis.
Here are some important things to know about vardenafil:
Quick Onset of Action
Vardenafil has the shortest onset of action among all PDE5 inhibitors. It takes effect within 10 minutes of taking the medication, making it a popular choice for those who want a fast-acting solution to their ED.
Duration of Effect
The effects of vardenafil typically last for 5 to 7 hours, but they may last up to 12 hours in some individuals. It is important to note that the duration of effect may vary depending on factors such as age, overall health, and dosage.
The recommended dosage of vardenafil is between 5 and 20 mg per day. It is important to follow your doctor’s instructions when taking this medication, and not to exceed the recommended dosage.
Common Side Effects
Like all medications, vardenafil may cause side effects. Some of the most common side effects of vardenafil include:
These side effects are usually mild and go away on their own. However, if you experience any serious or persistent side effects, you should contact your doctor right away.
The cost of vardenafil varies depending on the brand and the pharmacy. Staxyn tends to be cheaper than Levitra, and you can find generic brands of ED pills online easily available.
4. Avanafil (Stendra)
Avanafil (Stendra) is a medication used to treat erectile dysfunction. It was introduced to the market in 2012 and is a PDE5 inhibitor, like sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).
Duration of Effect:
Avanafil has a longer duration of effect than vardenafil and sildenafil but shorter than tadalafil. Its half-life is around 5 hours.
Avanafil is typically taken in a dose of 50 to 200 mg per day.
Common Side Effects:
Like other PDE5 inhibitors, avanafil may cause side effects. Some common side effects of avanafil include:
To understand how the best PDE5 inhibitors work, it is necessary to understand the process of achieving an erection. Sexual arousal activates the parasympathetic nervous system, leading to the release of nitric oxide (NO) that triggers the production of cyclic GMP.
This molecule causes relaxation of the smooth muscles inside the blood vessels of the penis and enhances blood flow.
The enzyme PDE5 breaks down cyclic GMP molecules, leading to the reversal of the erection process. This can cause erectile dysfunction, a condition where a man is unable to achieve or maintain an erection.
PDE5 inhibitors, which are similar in structure to cyclic GMP, bind to PDE5 and block its breakdown of cyclic GMP. This action enhances the effect of NO, promotes the relaxation of smooth muscles, and helps increase blood flow to the penis.
The vasodilating effect of PDE5 inhibitors on the penis helps the blood vessels relax and expand, leading to improved erectile function.
PDE5 inhibitors are a group of medications commonly prescribed for erectile dysfunction (ED). These medications have been found to be effective in treating ED. PDE5 inhibitors can be easily sourced from trusted ED suppliers, such as Mednova. However, it is highly recommended to consult with a healthcare professional before using any herbal supplements for ED treatment.